Abstract This paper deals with the existence and asymptotic analysis of positive continuous solutions for the following nonlinear polyharmonic boundary value problem:
\begin{align*}
\begin{cases}
(-\Delta)^{m}u= b(x)u^{p}, \ \ \text{in} \ D, & \\
\lim\limits_{|x| \rightarrow 1 } \big(|x|^{2}-1\big)^{1-m} u(x) =0, \\
\lim\limits_{|x| \rightarrow \infty } (|x|^{2}-1\big)^{1-m} u(x) = 0.
\end{cases}
\end{align*}
Here $m$ is an integer greater than 2, $p \in(-1,1)$, $ D$ is the complementary of the closed unit ball of $\mathbb{R}^{n} $ with $n >2m$,
and the function $b$ is nonnegative and continuous on $D$, satisfying some appropriate assumptions related to Karamata regular variation theory. 
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